Registration of new substances according to the German Chemicals Act (ChemG) under GLP conditions

We are a test laboratory certified as meeting the requirements of ‘Good Laboratory Practice (GLP)’ for registration of new substances or mixtures. We carry out the required physico-chemical investigations according to Directive 92/69/EEC (A.1. to A.17). In addition, we offer extra tests, some of which are required for registration of plant protection products, i.e. dust explosibility in a closed vessel, max. pressure increase (KSt) or particle size distribution.

We also undertake coordination and project management of the entire registration process in accordance with the German Chemicals Act (ChemG). Tests not offered by our facility (e.g. toxicity) can be carried out in cooperation with qualified and certified external laboratories.

A.1. Melting / freezing point (DSC) (OECD 102)
A.2. Boiling point (DSC) (OECD 103)
A.3. Density of solids / powders and liquids (OECD 109)
A4 Vapor pressure: Pressure range p < 10 Pa; vapor pressure balance (OECD 104)
A4 Vapor pressure: Pressure range 4 kPa < p < 100 kPa, dynamic method (OECD 104)
A4 Vapor pressure: Pressure range > 100 kPa (static method)
A.5. Surface tension (OECD 115)
A.6. Water solubility (retort method) (OECD 105)
A.6. Water solubility (column elution method) (OECD 105)
A.8. Distribution coefficient (HPLC method) (OECD 117)
A.8. Distribution coefficient (shake flask method) (OECD 107)
A.9. Flash point
A.10. Flammability of solids
A.11. Flammability of gases
A.12. Flammability (contact with water): Screening test
A.12. Flammability (contact with water): Complete test
A.13. Pyrophoric properties of solids and liquids
A.14. Danger of explosion: Screening test
A.14. Danger of explosion: Complete test
A.15. Ignition temperature (liquids and gases)
A.16. Ignition temperature for solids
A.17. Oxidizing properties: Screening test
A.17. Oxidizing properties: Complete test
C.7 Possible decomposition – abiotic decomposition – hydrolysis (OECD111) *
- Preliminary test
- Test no. 1, test no. 2, test no. 3

Test for determination of explosion properties according to VDI 2263, Part 1
Dust explosibility in a closed system
Explosion characteristics: pmax and KG value
Particle size distribution

Physico-chemical tests according to OECD test guideline
106: Adsorption / desorption

Adsorption coefficient (HPLC screening)
112: Dissociation constant in water
113: Thermal stability
116: Solubility of fats

We use supplementary analytical methods such as HPLC, GC, /VIS and elementary analysis (C, N,H). According to our quality management system, we can use these methods in compliance with GMP guidelines.