Siemens is represented in Karlsruhe by the Siemens Industrial Estate in the urban district of Knielingen.
The Siemens Industrial Estate is an open business park, hosting not only Siemens business operations but also those of other companies.
Siemens Development and Production Centres in the Östliche Rheinbrückenstraße and the Siemens branch office in the Siemensallee are located in an area covering 284.106 m².
Karlsruhe is the fifth largest Siemens business location including a centre for process automation, production automation, building automation and industrial services. The company is also the largest private-sector employer in Karlsruhe.